Document Details

Document Type : Thesis 
Document Title :
CU-NICOTINIC ACID COMPLEX NEUROPROTECTION, AND ALZHEIMER S DISEASE: EVIDENCE FROM ATTENUATED TOTAL REFLECTION- INFRARED SPECTROSCOPY (ATR-IR) IN AN ALUMINUM CHLORIDE RAT MODEL
الحماية العصبية لمعقد النحاس-حمض نيكوتينيك و مرض الزهايمر-دليل من مطيافية إنعكاس الأشعة تحت الحراء الإجمالي المخفف في طراز جرذ كلوريد الألمنيوم
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : The alterations of dynamic brain functions in Alzheimers disease remain far from well understood. The present study is designed to determine the protective effect of the combination of Coenzyme Q10 (10 mg/ kg.) and [Cu (I) (nicotinic acid) Complex (Cu+ N complex) (400 μg/kg.) against neural oxidative damage caused by aluminum chloride 10 mg/kg )induced rat model of AD in hippocampus rat brain, and were assessed by attenuated total reflection spectroscopy . Adult male Albino Wistar rat (N=20) were divided into; Control, AD, Cu+ N complex, Q10, and protective (Q10 and Cu+ N complex) groups. The overall findings demonstrate the alterations on the major biochemical constituents, such as lipids and proteins of the brain tissues of rat. Spectroscopic results revealed that AlCl3 caused a significant decrease in the lipid to protein ratio and the degradation of lipids into smaller fragments that contain less CH2 and more carbonyl esters, olefinic═CH and CH3 groups, which could be interpreted as a result of lipid peroxidation. AlCl3 altered the secondary structure of proteins by inducing a decrease in the β-sheet structures and an increase in the turns and random coil structures. AlCl3 group showed, a significant increase of APP and tau protein levels, and decreased in the GSH activity; and the histological examinations showed clumpy of cell neurons and scanty neurofibrillary tangle which was an indication of neurodegeneration when compared to the control group, behavioral deficits and histologic aberrations were attenuated on treatment with Q10 and Cu+ N complex. Conclusions: The present data advocate the possible beneficial effect of Q10 and Cu+N complex as protected modality for Alzheimers disease via its anti-inflammatory/antioxidant mechanism. 
Supervisor : Prof. Safaa Qusti 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Saturday, June 20, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
روان حمدان المروانيAlmarwani, Rawan ResearcherMaster 

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